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Doctors is set at the high-stakes Elizabeth Blackwell Medical Centre in Mumbai, where Dr. Nitya Vasu begins her surgical residency with a personal vendetta against Dr. Ishaan Ahuja, believing he is responsible for her brother's disability. However, as she works alongside him, Nitya realizes Ishaan is not the villain she thought, and her animosity turns to attraction. The series explores intense medical cases and the personal struggles of residents, including ambition, love, and betrayal. The season culminates in shifting relationships, with old enemies becoming allies, a tragic event reshaping the group, and Nitya and Ishaan's love emerging at great personal cost.